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With less than 50 presumably unrelated individuals [there are 53 individuals reported as unrelated in the HapMap ASW dataset, even if we ignore the relationships reported here and in Pemberton et al. (2010)], the estimation of allele and haplotype frequencies becomes problematic, especially in an admixed population like ASW.
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The yellowing can become problematic especially in fine art drawing rather than newsprint where text can often still be read.
This becomes problematic especially for tumor samples where the majority of the genome is often not expected to be diploid.
Communication with staff can become problematic, especially when children have additional needs necessitating clear lines of communication.
However, the end-to-end performance becomes problematic in multi-hop wireless networks.
Hence, prescribing the heat fluxes becomes problematic in the existing MPS method.
This term becomes problematic in the recursive dynamic programming optimization framework we describe below.
With her own team of ministers in place and the memory of the Lula years fading, the president is likely to face a less accommodating public if corruption scandals remain in the headlines, especially if the economy becomes problematic.
"That's problematic, especially in this economy," he said.
Migration is problematic, especially in estimating populations for small areas.
Differentiating residual or recurrent cancer from scar tissue is problematic, especially in patients with ongoing symptoms.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com