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However, culture is a notoriously slippery concept that in practice is hard to operationally define, and this state of affairs becomes particularly problematic for instructional designers who need to identify such local teaching cultures prior to creating programs that build on existing practice while also attempting to change it.
The alternative approach of asking the proxy to estimate the patient's level of concern may be more likely to produce missing values and becomes particularly problematic for patients with severely compromised cognition.
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This heinous attempt to mischaracterize gay men as "child predators" and "recruiters" for homosexuality becomes particularly problematic in domains where the care of children is of paramount importance, such as in schools and activity-based organizations (e.g. Boy Scouts).
"This becomes particularly problematic when you're casting a video for a song entitled We Exist.
When crop residues have been completely grazed, and especially when finding water for the herd becomes particularly problematic, some pastoralists decide to send their herds on transhumance.
One key obstacle when implementing true research-oriented laboratory modules is the availability of tested procedures/techniques; this becomes particularly problematic when the lab exercises are designed for students in very large classes.
This becomes particularly problematic in northeastern and Rust-Belt cities that are losing population.
This becomes particularly problematic in the Act II "Loveland" numbers, where each character dives head first into mental collapse.
This becomes particularly problematic in our epoch of a borderless War on Terror that can never be won or lost.
This becomes particularly problematic in convincing companies to produce age-appropriate strengths of fixed-dose combination ARVs in multiple formulations.
This was often attributed to a lack of connection between mental and physical health services, and became particularly problematic when service users were hospitalised in a crisis, for either their mental or physical health problem.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com