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Because of genetic drift, predicting FST becomes particularly more difficult when more barriers separate populations.
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Taking medications as prescribed becomes particularly difficult for individuals with multiple chronic conditions.
The larger and more complex a model, the more difficult validation becomes, particularly when data are limited.
Things became particularly difficult when his novels were published and her more experimental work was not.
In turn, differentiation becomes more difficult.
Issues became particularly difficult with going global, regional networks.
These limitations become particularly difficult when researching rare events such as the pharmacogentics of adverse events.
They are placing more importance on turning consumers into customers, particularly as it becomes more difficult and expensive to prospect for computer users who have still not visited their sites.
"The search for independent directors has become far more difficult, particularly for the audit and compensation committees," says Paul P. Brountas, senior counsel for Boston-based Hale and Dorr.
And particularly once you start splitting them over jurisdictions and things like that it becomes much more difficult to subvert their intentions.
"Market timing becomes much more difficult.
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