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Upon Na+ binding, it either reorients or becomes ordered and then runs more or less perpendicular to the membrane plane.
For IsdHN1 and IsdHN2, this disordered loop becomes ordered and forms a short α-helix upon binding to metHb, as observed in the crystal structures of these two NEAT domains of IsdH in complex with metHb.
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The originally studied Lfc2 and Com4 peptides were found to be unstructured in aqueous solution and they become ordered and adopt a well-defined conformation when bound to lipid membranes [42], [43].
TM2 and its linkers to TM1 and TM3 become ordered, and so do the cytoplasmic half of TM6 and part of the linker between TM6 and TM7.
This was in contrast with the predominant theory that ELP was soluble below the TT and then became ordered and aggregated in an all-or-none manner.
Interestingly, it is only when the second Mg2+ ion is bound that all of the residues and the phosphates at the active site cleft become ordered and could be resolved crystallographically (24).
Once nickel ions bind to NikR, the α3 helices and loops preceding them become ordered, and this allows the protein to interact with DNA through nonspecific hydrogen bonds to backbone phosphate groups.
The aim of the update process is to make neurons more like the input vector; the end result is that the neurons on the map become ordered and neighboring neurons are similar.
BBL becomes ordered on biotin binding and then adenylate binding site is formed in EcBirA.
My previously aimless days of wandering and dreaming became ordered by meals and domestic chores, by managing the increasing responsibilities of two homes and their attendant minutiae.
A number of these interactions occur within the structurally conserved domains of MTA1, but others are directed through intrinsically disordered regions that become ordered on binding and are key to forming a stable NuRD complex.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com