As the science of physics expanded to cover an ever-wider range of phenomena, it became necessary to include additional forms of energy in order to keep the total amount of energy constant for all closed systems (or to account for changes in total energy for open systems).
As the number of religiously unaffiliated people climbs, and a younger generation becomes a more influential voice in society, it will become necessary to include and understand these voices in our broader national discourse.
As none of the presently available inhibitors of autophagy function exclusively in autophagy regulation, it became necessary to include genetic inactivation of essential autophagic proteins to establish the role of autophagy in cell death.
Thus, it becomes necessary to conduct further studies that include follow-up assessments in the medium and long terms in order to obtain more accurate conclusions about the efficacy of Back Schools.
As a result, it becomes necessary to analyze architecture in a way that includes the operational contexts-of-use within which systems are being used.
It therefore becomes necessary to test a diagnostic tool in a broad spectrum of patients, including a control population of non-RA rheumatic conditions, in order to be appropriately validated.
When doing so, it becomes necessary to work with multinomials rather than binomials; however, the general approach, including the estimation of multinomial probabilities, is closely analogous to the procedure just described.
For targets with wide nucleotide diversity, it becomes necessary to develop a set of signatures, for which we suggest a minimal set clustering approach that may also include signatures with degenerate/inosine bases.
