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However, if generalised SBP operators are used, the treatment of the boundaries becomes more difficult since some properties of the continuous level are no longer mimicked discretely — interpolating the product of two functions will in general result in a value different from the product of the interpolations.
However, the study of problem (1.1) becomes more difficult since M is a general function.
On the other hand, if one constructs small-scale synteny blocks, then rearrangement analysis becomes more difficult, since small-scale blocks are more likely to exhibit structural variations and are also more susceptible to be incorrectly identified (false synteny blocks).
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