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The Sumo-specific E1 enzyme [the heterodimeric complex between Uba2 and Aos1 (yeast; termed Sae1-Uba2 in mammals)] initiates the process by first catalyzing adenylation of the Sumo C-terminus, which next becomes linked by a thioester bond to Uba2's catalytic cysteine [9], [10], [11], [12].
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Furthermore, highly deleterious, yet recessive, mutations may persist in heterozygosity until a compensatory partner arises or becomes linked by recombination.
In the end, if nothingness equals nihilism equals nonsense equals nowhere equals the ineffable equals anarchy equals opposition to the powers that be, then all art eventually becomes linked by six degrees of separation.
The two owners became linked by Prof. Vivian Pfeiffer (played by John Cullum), the grandson of the robber baron and a well-known expert on New York City history.
The SiO4 tetrahedrons thereby become linked by shared oxygen atoms; this is referred to as polymerization.
Lahore and Leeds have become now become linked by four names: Mohammad Sidique Khan, Shehzad Tanweer, Hasib Hussain and Jermaine Lindsay, also known as Lindsay Jamal.
He controlled the Greek and Sicel communities of east Sicily and became linked by marriage with Theron, tyrant of Acragas (later the Roman Agrigentum, modern Agrigento).
On 21 Jun, the route was extended both to the north and to the south so that Frankfurt and Nairobi became linked by the same corridor, operated with DC-6Bs.
During the self-organization process, some of the clusters became linked by bundles of axons.
The 'endosome/autophagosome' hybrids moved toward the nucleus where they become linked by tubular extensions, and fused with one another.
The part of the levy that is more tentative is the proposal that the flat levy becomes linked to the systemic risk posed by a bank over time.
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