Accordingly, many studies have shown that disruption of the TGF-β signalling early in metastasis can substantially reduce metastasis burden and that the effect becomes less effective when lesions become well-established [ 59- 61].
The two main maternal influences on Maya's life change as well; Vivian becomes a more active participant, while Momma becomes less effective as Maya, by becoming a mother herself, moves from childhood to adulthood.
However, there is some evidence of a threshold effect, at which exercise becomes less effective in combating age-related increases in arterial stiffness.
However, it becomes less effective over time and causes abnormal involuntary movements (dyskinesia).
Neurons in ageing brains lose their connections and start to die off; ultimately, the brain shrinks and becomes less effective.
However, every defender who adjusts his behaviour to protect against this threat becomes less effective at obstructing a kick.
However, Dr Lenton notes that the method becomes less effective as the atmosphere becomes more saturated with particles.
Not enough research has been done, she said, into how quickly the vaccine wears off and whether it becomes less effective when repeated.
"From speaking to colleagues and reading through the threads, it appears that the on/off trick becomes less effective as the save file keeps growing.
As they get the treatment more and more it becomes less effective as people become resistant, so the doctor escalates the treatment.
Such a process, however, cannot go on for ever, because with each increase in size, the IMF's board becomes less effective.
