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This antiviral T cell population becomes functionally impaired or is deleted early in the course of disease in those where viremia persists.
Our data indicate that the NSC niche becomes functionally impaired following radiation exposure and during aging.
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As a consequence of aging, misfolded proteins accumulate over time and proteostasis pathways become functionally impaired in response to persistent or repeated environmental exposures, thereby amplifying protein damage [6].
Ultimately, senescent CNS cells become functionally impaired and eventually die, and this neurodegeneration leads to brain organ failure.
Parkinson's disease (PD) is a neurologic movement disorder in which neurons of the substantia nigra, which are responsible for dopamine production, attenuate in number or become functionally impaired.
The tendency to place this older patient ahead in the queue was lost as the patient became more severely functionally impaired.
Upon stimulation, the SPS is phosphorylated and becomes functionally active.
The mechanism by which a van cluster becomes functionally integrated into bacteria is not known.
During the oxidative burst, ProDH becomes functionally uncoupled to P5CDH and apparently works with P5CR.
In this case the functionally impaired circuits might become reorganised and repaired in the most effective manner.
In turn, Parkin promotes the degradation of functionally impaired mitochondria through ubiquitination-dependent autophagy [11], [12], [13].
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com