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In this situation maintenance becomes extremely problematic as within such a high-performance network a relatively minor fault will impact more trains and passengers; such denial of service causes reputational damage for the industry and causes fines to be levied against the infrastructure owner, Network Rail.
When school is in session, traffic congestion in this area becomes extremely problematic in the mornings, typically around 8 a.m.
Species richness only analyzes the abundance of taxa at a site, and becomes extremely problematic when we lack tight control over the rate(s) of fossil accumulation at a site.
Figure 1 would suggest, therefore, that designing 10-plex assays from N = 1,200 SNPs is generally straightforward, but that increasing multiplex performance to 15- to 20-plex or beyond becomes extremely problematic.
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Since Bordo Poniente - one of the world's largest landfill sites - was closed last month, the question of how to dispose of the city's rubbish has become extremely problematic.
This is even more problematic at later stages, when the ZA becomes extremely disrupted (see current Figure 5B).
Thus, recognition of archaeological sites and relict landscape features becomes extremely difficult, whereas standard landscape analysis and application of mainstream Remote Sensing (RS) techniques based on multispectral satellite images are problematic.
Chaparral vegetation becomes extremely dry by late summer.
This is where "Netherland" becomes extremely subtle.
View creation becomes extremely complex.
And that becomes extremely strong.
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