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It is delocalised from the nucleus in an HU-dependent manner on activation of Cds1, the fission yeast S phase checkpoint kinase, but becomes essential for viability on recovery from replication arrest [29].
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The repeat domain of Nsp1p becomes essential for the viability of Saccharomyces cerevisiae when certain other FG repeat domains are deleted (Strawn et al, 2004).
The replication stress checkpoint is active during this interval, and it becomes essential for G1 arrest and viability if Cln3 is overproduced (Miles et al. 2013).
After extensive β-cell ablation, adiponectin becomes essential for survival.
However, two cytosolic PPIases, PpiB and trigger factor, in Bacillus subtilis have been shown not to possess an essential function under normal growth conditions, but they become essential for cell viability under starvation conditions [ 13].
In general, targeting influential genes as they become essential for tumor viability throughout the adaptation process presents an opportunity to enhance the effects of molecularly targeted drugs by staying a step ahead of resistance.
Lhp1 is not an essential protein, but it becomes indispensable for viability in strains harboring specific additional mutations.
When competitiveness and limitation of resources are essential for the viability of any product it becomes essential to find a universal system adapted to the requisites of any country.
A fixed point in time for outcome assessment becomes essential.
The need for high performance computing becomes essential.
Integration becomes essential.
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CEO of Professional Science Editing for Scientists @ prosciediting.com