However, as cells acquire resistance to vorinostat during the course of long-term exposure, autophagy becomes essential for cells to survive vorinostat toxicity, and therefore, cells gain sensitivity to inhibitors of autophagy.
However, two cytosolic PPIases, PpiB and trigger factor, in Bacillus subtilis have been shown not to possess an essential function under normal growth conditions, but they become essential for cell viability under starvation conditions [ 13].
After extensive β-cell ablation, adiponectin becomes essential for survival.
When non-dividing cells are exposed to severe stresses, mitophagy becomes essential for the maintenance of healthy mitochondria.
Oncogene upregulation becomes essential for increased glucose and glutamine metabolism following respiratory impairment (83, 165).
With VCD being controlled, increasing qP then becomes essential for protein productivity.
The implication is that a treatment-induced pathway then becomes essential for tumour survival.
These dormant origins can be activated when replication is inhibited, and become essential for complete replication and cell survival (Woodward et al, 2006; Ge et al, 2007; Courbet et al, 2008; Ibarra et al, 2008).
DNA extraction from microdissected cells has become essential for handling clinical specimens with advances in molecular pathology.
Several integrins are switched off in order for cells to detach from the basement membrane, and others now become essential for wound migration.
