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Although there is no specific research on the relationship between fast food adverts at a large sporting event and obesity, Dr Keegan believes such adverts could have a direct impact on the obesity epidemic, especially for people who already regularly eat unhealthy foods, as it becomes "difficult to change that pattern".
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A real difficulty these teachers envisioned in teaching about shared British values was that cultural values when internalised are durable and become difficult to change.
Smaller or newer companies aren't constrained by supply chains that have grown up over the years and become difficult to change.
This is because habits are formed early in life and become difficult to change later in life [ 31].
Q: Why does the drop in under-5 mortality seem to reach a plateau at a certain level and become difficult to change?
With respect to negative selection on high performance fishes, we speculate that once a reasonably efficient OXPHOS system evolved it may have become difficult to change in the high performance groups.
In this case it becomes difficult to separate physiological changes that result from morphological alterations as opposed to abnormal cell signaling.
It becomes difficult to determine how much change is a product of trial processes, or directly attributable to changes in services delivery, and whether any of the observed changes will be sustainable [ 5, 6, 16].
It then becomes difficult to ascertain how these changes will eventually reflect in costs, which makes the capital costs component of nuclear power plants uncertain.
Some caution needs perhaps to be exercised in interpreting the results from the Social & Family Well-being scale, particularly when employing a single score as an index of a clinically meaningful difference [ 5], since if the subscales do not represent a single underlying construct it becomes difficult to draw valid conclusions from a change in scores [ 12].
Therefore, if there are no or very little morphologic changes, it becomes difficult to identify drug targets.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com