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It is so nonsensical that it becomes difficult to argue with.
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If diphthamide-deficient mutant eEF-2 proteins function perfectly well, it then becomes difficult to understand the retention of the diphthamide modification in such a diverse set of species, which argues strongly for its essentiality.
9 10 Role theory argues that inter-role conflicts experienced by individuals will result in an undesirable state, if it becomes difficult to fulfil each role successfully owing to conflicting demands on time and behaviour among roles.
It becomes difficult to maintain faith.
It becomes difficult to move.
My sense of taste changes, it becomes difficult to eat.
TB like HIV/AIDS becomes difficult to discuss in public.
It becomes more difficult to argue against female objectification if do the same to men, albeit in a watered-down, complimentary sort of way.
However, when sustainability is recast as being fundamentally about the way a company does business – including how it recruits and retains talent, ensures security of resource supplies, and ensures customer satisfaction and good stakeholder relations – it becomes more difficult to argue that these have a marginal impact.
This scepticism inevitably moderates Godwin's belief in perfectibility, since it becomes more difficult to argue for convergence on principles of morality and the progressive development of knowledge.
The consistency "doesn't prove we're right," says Jackson, "but it becomes pretty difficult to argue it's all serendipitous".
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com