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Under such circumstances, establishing the diagnosis of PKDL and differentiating it from leprosy by traditional methods becomes difficult particularly for macular/papular cases and real time PCR assay provides a reliable alternative, being faster than routine PCR.
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"The search for independent directors has become far more difficult, particularly for the audit and compensation committees," says Paul P. Brountas, senior counsel for Boston-based Hale and Dorr.
With such differing protocols, effective comparison between trials becomes problematic, and quality assurance of specific radiotherapy techniques difficult, particularly for the more complex planning specifications.
In this environment sex and relationships become difficult and, particularly if relations sour, hugely disruptive for the wider team.
Living there was difficult, particularly for the children.
Both events will be immensely difficult, particularly for Lorna.
Access to primary care is, however, difficult, particularly for the economically disadvantaged; quality may be mediocre; and the payment system is antiquated, with many valuable functions unrewarded, leading primary care to become an unattractive career choice.
Gambling becomes difficult.
It becomes difficult.
Thus, prediction becomes difficult.
It will eventually become difficult for workers to implement online screening of clients and outreach to other workers, particularly via American hosted platforms like Facebook and Twitter.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com