Sentence examples for becomes deleterious from inspiring English sources
Here, we analyze the phenotype of RhoE null mice and show that RhoE is essential for a correct development since the absence of RhoE expression induces severe behavioral and structural alterations and becomes deleterious few weeks after birth.
Despite some convincing experimental data, no clinical trial has established the level at which pH becomes deleterious for hemodynamics.
The authors demonstrate that gltA1 can increase fitness on acetate, but that the mutation becomes deleterious once cells have acquired the ability to utilize citrate.
15 Despite an initial haemodynamic benefit, RV dilation becomes deleterious and a vicious cycle is established between RV enlargement and the decrease of cardiac output.
NO generally mediates beneficial responses, but becomes deleterious when coexistence with enhanced superoxide formation leads to the synthesis of peroxynitrite, a potent oxidant and nitrating agent [ 7].
Consequently, BRC-1/ BRD-1 activity in smc-5 mutant cells becomes deleterious as it leads to the induction of HR that cannot be resolved in the absence of SMC-5/ 6, thus leading to genome instability in proliferating cells.
Interestingly, surgery did not become deleterious, whereas medical management improved.
However, during septic shock, immunothrombosis may also become deleterious, contributing to major tissue insult and excessive coagulation activation [11 13].
On the other hand, thrombin can become deleterious if ongoing activation of the coagulation, owing to defective natural anticoagulants, leads to excessive thrombin formation.
Further studies need to confirm these data and to evaluate more precisely at which time point of the growth period and from which amount a localized peripheral growth plate injury may become deleterious for further longitudinal growth.
The concept of a Darwinian-evolutionary basis for the development of age-related diseases in principle postulates that genetic traits that are beneficial in younger years to allow for successful reproduction may become deleterious in the elderly, i.e. when selective pressure does not seem to be effective anymore.
