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Such instructive functions by the Rb family during cell fate determination may no longer be required once a cell becomes committed to a specific lineage, and the major function of Rb in committed cells might be to allow proper cell cycle exit and survival; a function that can be bypassed by survival factors or hypoxia.
"She quickly becomes committed to a riskier older man in an unsupervised setting, which is where the bad guys are," said Dr. Ehrensaft.
Once a cell becomes committed to a particular fate, it shouldn't be able to become something else.
In principle, such unspecialized cells are considered to be quiescent, but capable of self-renewing; their asymmetric division produces one identical daughter stem cell and a second progenitor cell that becomes committed to a lineage-specific differentiation program [ 1].
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But it was not until after the catastrophic flood of 1927 that the federal government became committed to a definite program of flood control.
By their past actions — and through the arbitrary fact of having been born in one place rather than another — they have become committed to a view of the world which they are unwilling to revise.
At the age of 10, she was cast as Dorothy in a school play of The Wizard Of Oz and when she realised she could make the audience laugh by improvising with the dog playing Toto, she became committed to a life in comedy.
Retinoids appear to determine whether tracheal epithelial cells become committed to a pathway of squamous differentiation or to a mucosecretory pathway of differentiation.
To identify when cells become committed to a novel phenotype and will continue to produce and accumulate lipids without external stimuli, we designed the following experiment.
When exiting the mitotic phase, neural progenitor cells will eventually become committed to a specific neural cell lineage and start to differentiatiate.
As cells within the developing clusters move away from the aortic wall and the source of BMP, they lose multipotency and become committed to a haematopoietic fate.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com