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The chronological age at which immunosenescence becomes clinically important is most likely influenced by many factors, including the pathogen load to which individuals are exposed throughout life.
With the availability of effective anti-EGFR therapies for various solid malignancies, such as NSCLC, CRC and HNSCC, the knowledge of EGFR and K-RAS status becomes clinically important.
We a priori dichotomized patients into two groups: those reporting joint pain severity from 0 3 and those reporting joint pain from 4 10, a level at which pain becomes clinically important and interferes with daily functioning [ 19].
A continuum of risk for the development of diabetes across a wide range of subdiabetic A1C levels may make the classification of individuals into categories similar to IFG and IGT equally problematic for A1C, as it implies that we actually know where risk begins or becomes clinically important.
With the availability of effective anti-EGFR therapies for various solid malignancies, such as non-cell small lung cancer, colorectal cancer and squamous cell carcinoma of the head and neck, the knowledge of EGFR and K-RAS status becomes clinically important.
However, the CI-AKI Consensus Working Panel agreed that the risk of CI-AKI becomes clinically important when the baseline serum creatinine concentration is ≥1.3 mg/dL (≥115 μmol/L) in men and ≥1.0 mg/dL (≥88.4 μmol/L) in women [ 86].
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We might not appreciate late cardiovascular sequelae that may become clinically important later in life.
Metastatic spine tumor has become clinically important because of the availability of improved diagnostic tools and increases in survival periods in cancer patients.
Although the effect of HAART was small, the subjects in our study were young and the mild changes identified here could become clinically important over a lifetime of antiretroviral therapy.
Although the differences observed in gait were subtle, they may become clinically important in young or active patients who engage in high-level activities over many years.
P. aeruginosa represented a prominent healthcare-associated pathogen and B. cereus was chosen to represent spore-forming species which might also became clinically important particularly in food poisoning [ 16, 21].
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