With added databases, most unclassified (derived from Bacteria) by mg-RAST analysis became annotated.
The better genomes become annotated with cryptic transcriptional elements and non-coding transcripts, the better the functional impact of epigenetic marks and histone signatures is understood.
When gene structure becomes better annotated, we might discover that many genes have multiple alternative 5' or 3' UTRs for transcription, so that two neighboring genes may become overlapping with each other in certain transcribed forms.
Finally, as the bovine genome becomes better annotated, it can serve as an interim platform for many other agriculturally important animals, such as sheep and goat, until their genome sequences become available.
In addition, this approach normalized variations in annotation practice of public databases as each molecular function term became always annotated beyond that to its biological process and cellular component; making the annotation more consistent and more robust.
As the bovine genome becomes better annotated it can in turn serve as the reference genome for other agriculturally important ruminants, such as sheep, goat and deer.
QTL resolution remains coarse for these regions, as the cattle genome becomes more completely annotated these regions may identify useful targets of selection.
We would hence expect better results in some of these pathways as some of these functions become more thoroughly annotated.
Applying such a set of rules, it becomes possible to annotate sites onto multiple genomes without generating a large number of false assignments.
As more genomes become sequenced and annotated to higher quality, these findings can be validated further, elucidating the role of genome maintenance in modulating lifespan.
