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When the response of interest is based on a time to event outcome (e.g., one-year survival), censoring becomes an issue during the interim analysis, as it is unclear how subjects without sufficient follow-up should be handled.
Place a nursing pad in the bra if leakage becomes an issue during the night.
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Trump's hand size became an issue during the Republican primary.
Djokovic is that rare men's player whose family has become an issue during his formative years as a star.
That arrangement became an issue during his winning 1998 campaign, when it became clear that he had done little in the way of paying off the debt.
executive vice president, part of which was eventually forgiven, became an issue during Mr. Lew's confirmation hearings as treasury secretary this year.
When the newsletters first became an issue during his Congressional campaigns in the 1990s, however, he did not deny writing some of them or knowing about them.
His second marriage became an issue during the bitter Republican primary this spring, when a top aide to his opponent, Kathleen Troia McFarland, called Mr. Spencer a bigamist.
Russia even became an issue during an election campaign which ignored the world outside Germany in every other respect: SPD chancellor candidate Peer Steinbrück accused Merkel of doing too little to get Putin to co-operate on Syria.
For ciprofloxacin, the antibiotic whose patent status and high price became an issue during last year's anthrax scare, the patent owner, Bayer, is not on the list as a safe supplier for AIDS-related infections.
Even last week, the merit of flying the Confederate flag above the Statehouse in Columbia, S.C., which had become an issue during that state's presidential primary, was still being debated.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com