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Since SOD1-mediated ALS in transgenic mice is dosage-dependent (3, 18, 19), and NMD affects ∼80% of the SOD1 mRNA with a PTC, thus preventing high expression of the mutant SOD1, it becomes a technical challenge for defining the ALS-associated polypeptide or domain further upstream in SOD1.
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Then the 45-degree slope becomes a technical ice climb.
Designing algorithms that can robustly and efficiently handle unstructured urban models at the city scale becomes a main technical challenge.
Surgical access to the infralaryngeal trachea becomes an insurmountable technical challenge, even when attempted percutaneously.
"It was quite a technical challenge.
The sheer scale of the display is a technical challenge.
A man in Wisconsin viewed it as a technical challenge.
So it's an imaginative leap and a technical challenge".
It is a technical challenge that could cost $16 billion.
They perceived "converting ebooks" as a technical challenge beyond the average book buyer.
This wasn't just a technical challenge.
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