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The fact is that catheterization of the femoral artery is a more and more performed procedure in everyday clinical practice, and the incidence of the postcatheterization PSA becomes a clinically relevant concern [2, 3].
Also, due to increasing amongst drug abusers [ 20- 22], xylazine-induced hyperglycemia potentially becomes a clinically relevant issue, especially in diabetic subjects.
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A modified mRNA vaccine can prevent ZIKV disease and be adapted to reduce the risk of sensitizing individuals to subsequent exposure to DENV, should this become a clinically relevant concern.
Potentially, Ds may become a clinically relevant biomarker of disease activity in UC.
These results highlight the importance of screening for silent AF, which may eventually become a clinically relevant arrhythmia.
Therefore, methylation of MGMT has become a clinically relevant predictor of response to treatment in glioma patients [ 7– 10].
If genetic variation is to become a clinically relevant biomarker, it is essential that there is a clear understanding of genotype phenotype relationships.
Inhibition of the VEGF/VEGFR system has already become a clinically relevant strategy for innovative treatment of several urological tumours (Krause and Van Etten, 2005; Chieffi, 2007).
This is especially noteworthy because metastatic cells must be able to proliferate effectively at a distant site in what must be considered a foreign microenvironment, if they are to become a clinically relevant metastatic lesion.
Inhibition of the VEGF/VEGFR system has already become a clinically relevant strategy for treatment of some urological cancers, especially those refractory to the standard chemotherapy (Voigt et al, 2006; Fenner et al, 2008; Castillo-Ávila et al, 2009), whereas TGCTs are not systematically analysed in this respect.
Further technical development, such as 3D image acquisition to overcome challenges pertaining to single-slice data (including registration errors), rapid image analysis and improving signal-to-noise ratio, is required before pH-weighted imaging becomes a widely clinically relevant imaging modality influencing treatment decisions for individuals.
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