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When QIBs become validated endpoints, this has important clinical implications as ineffective treatment can be modified earlier.
The NPSC anticipates increased use of contextual databases as a resource for the generation of gene expression signatures or motifs that could eventually become validated biomarkers of toxicity.
Furthermore, the analysis provides information about the entire genome, making it feasible to obtain data from other genes of interest, such as TOP2A, as they become validated for breast cancer diagnosis.
Although "omics" methodologies require increasingly sophisticated computational and mathematical tools which are only beginning to unravel its full potential we believe the systems assumption that the forest (e.g. preterm labor) cannot be explained by studying the trees individually (one by one factor) will become validated [ 13].
But as generations grow up and culture moves on then they become validated by figures of authority and are perhaps less subversive".
There are a larger number of people who enjoy coming on when an idea has become validated and thus "de-risked" but I still think this is a small number of people.
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While transcriptomics can shape future biomarker development, currently < 1% of published biomarkers become clinically validated tests, often due to poor study design or lack of independent validation.
Bcl-2 proteins, such as B-cell lymphoma (Bcl-2) protein, myeloid cell leukemia sequence 1 (Mcl-1) protein, has been implicated in the progression and survival of multiple tumor types and become a validated and attractive target for cancer therapy.
"Some people will argue that it's a shame that [this model] is reappearing, but for the social space, it's necessary to become more validated against the marketer's budget," Sethi says.
Therefore, caspase-3 inhasition has become a validated therapeutic approach for neurodegenerative disorders.
In the 1990s, it became a validated therapeutic target used for the treatment of conditions such as rheumatoid arthritis and inflammatory bowel disease.
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