A group of kids who had grown up together in south London became the breakthrough act of the year; their meteoric rise looked like a cause for celebration.
In the 1990s, just out of college, Andreessen went knocking on VC doors in Silicon Valley, looking to fund what became the breakthrough web browser Netscape Navigator.
In the late 1990s, the potassium channels became the breakthrough point for the structural studies on VGICs (Doyle et al., 1998; Jiang et al., 2002; Jiang et al., 2003; Long et al., 2005; Long et al., 2007).
He translated several international hits into Finnish, including Piilopaikka ("Hideout", originally "You've Got Your Troubles") by Danny and Nyt meni hermot ("Now I'm Furious"), which became the breakthrough recording of pop group "The First".
Eternal inflation offers a viable alternative that is untenable in a finite universe, i.e., that a coupled system of translation and replication emerged by chance, and became the breakthrough stage from which biological evolution, centered around Darwinian selection, took off.
With less reverence toward history and more susceptibility to rhythm, the new plan to develop the Coliseum site on Columbus Circle could become the architectural breakthrough New York has been waiting for.
(Larry Page, one of the company's founders, was a trailblazer; in 2001, he collected images by driving around town with a video camera mounted to the side of his car). Eventually, Street View would become the next breakthrough for Google Maps after the introduction of its programming interface.
Each had the potential to become the next breakthrough in maternal and infant health -- the ultimate aspiration of an international partnership called Saving Lives at Birth: A Grand Challenge in Development with the Bill & Melinda Gates Foundation, Grand Challenges Canada, the Government of Norway, and The World Bank.
If foundations began to finance public advocacy — and just small grants are needed — there could be thousands more changes for the good happening, and some might eventually become the large breakthroughs we all want.
