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It has also been hypothesized that self-reactive memory B cells accumulated with age may become reactivated later in life due to deficiency in immune tolerance leading to elevated autoantibody levels in the elderly (Stacy et al., 2002).
These genes, dormant in adults, often become reactivated in a type of cancer known as non-small cell lung tumors.
But their ideas run counter to another theory, that brain circuits that were activated during wakefulness become reactivated during sleep, consolidating learning by making these synapses stronger.
But over time, soil can absorb the urea, which may allow the prions left behind to refold and become reactivated, Dr. Gabizon said.
Clustering showed a distinct separation between the 4- and 5-h nuclei that were predicted to become reactivated and those that did not (Fig. 6e).
Amounting evidence indicate that the developmental pathways, such as Hedgehog (Hh), Wnt and Notch, become reactivated in gemcitabine-resistant cancer cells.
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It is unclear whether HCMV plays an active role in malignant tumor progression or becomes reactivated under pathologic conditions that result in chronic inflammation or immunosuppression.
The team notes that eIF2α becomes reactivated after a certain amount of time through pathways that guanabenz does not act upon, so eventually the stress response mechanism will shut down, regardless of treatment.
The molecular mechanism by which JCV becomes reactivated in immunosuppressed individuals is unknown.
Accordingly, one may speculate on the involvement of inducible glial specific activator which becomes reactivated and promotes JCV gene transcription and replication during the course of immunosuppression.
Skewed XCI is known to happen during mouse embryogenesis at the two cell stage until the blastocyst stage when the inactive paternal X becomes reactivated.
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