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Another option is that intracellular concentration of itaconate and the lack of transport capacity might become rate limiting, which was also proposed by Okamoto et al. (2014).
The macropore diffusion should be rate limiting if the parameter α > 10−1 and the micropore diffusion become rate limiting if α < 10−6.
As the number of compounds submitted for in vitro ADME screens increases, data analysis, interpretation, and reporting will become rate limiting in providing ADME structure-activity relADME structure-activityo guide the synthetic strelationshipheminformation.
Furthermore, the measurement of deuterium kinetic isotope effects using [1(S -2H]DHAP S -2H]DHAPt, for the wild-type enzyme, proton abshowedion was nothate rate determining step, whereas in the case oforhe E182A muthet this step had become rate limiting, providing evidence for the role of Glu182 in abstraction of the C1 proton from DHAP in the condensation direction of the reaction.
Speculators and owners of structured product have become rate easing and assistance junkies.
Only under some artificial conditions (cobalt limitation [57], [60]) coenzyme-B12 dependent reactions of the ethylmalonyl-CoA pathway may become rate limiting.
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Besides the effects of environmental conditions on oil biodegradation, other factors intrinsic to oil, such as oil solubility, partition coefficient, dissolution rate, viscosity and physical state become rate-limiting in the cell-oil uptake and biodegradation by the cell.
Only when Ena levels are reduced (ena−/+), does additional reduction of profilin (chic−/+) become rate-limiting, thus explaining the reduction in filopodia numbers in ena−/+ chic−/+ neurons.
As clone F2 express high level of Nox2 but very few Hv1, the above results support the notion that charge movement through Hv1 can become rate-limiting for very intense ROS production in human cells.
Moreover, we improved the cost-efficiency of the overall assay by decreasing the reagents' concentrations of the secondary (light-producing) reaction, while ensuring that they do not become rate-limiting for the processing of the PPi product of the primary (polymerase) reaction.
Indeed, diffusion will always become rate-determining if solubility is low and nucleation occurs from very sparse solution.
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