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Central sensitization could become progressively more severe over time and, by an imbalance between the inhibition and the facilitation of pain dynamics, might contribute to chronification phenomena, interictal CA and probably pain perception abnormalities.
As expected, these mice begin to show mild spinal kyphosis and reduced body weight by 4 weeks of age, both of which become progressively more severe over time.
Externally, xav mutants cannot be distinguished from WT until after 48 hpf, when they start to exhibit a bent tail and slower heart beat, phenotypes that become progressively more severe (Figure 1A, 1B).
Estimation of divergence dates for biological taxa from molecular data is a perilous exercise fraught by artifacts which become progressively more severe for events further in the past [ 1, 2].
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Scanning electron microscopy revealed that, at the highest stresses studied, surface cracking occurred, which became progressively more severe as the time of treatment increased.
Externally, srn mutants exhibit a bent tail as early as 24 hpf, a phenotype that becomes progressively more severe (Fig. 1A), as well as a malformation of the hindbrain, which becomes apparent at 48 hpf (Fig. 1A, brackets).
These defects became progressively more severe at P14, P21 and the adult stage (P42).
Untreated mild heat illness (heat exhaustion) becomes progressively more severe (heat stroke).
His symptoms became progressively more severe during the next 2 days, and fever reached 39.4°C.
A general observation was that the microscopic changes in Experiments I and II became progressively more severe.
These alterations became progressively more severe with ∼6% of affected fibres at 2 weeks of age and reaching 40% in 80-week-old Fgd4 − / − mice.
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