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Furthermore, the amount of collected data could become problematic within the evaluation process.
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Repeated or large volume blood collection may also become problematic as the disease progresses.
A low specificity could become problematic if the volume of events reported through Annex 2 increased.
The triple injection had become problematic because Georgia was running out of the drugs in question.
Within our consent protocol alerts were built in instructing the nurses to consult with senior members of the research team should the consent process become problematic (see 'Consent Protocol' and 'Consent Pathway' in *supplementary information and on Newcastle 85+ website).
Even footing the bill for the 6m Iraqis on the government payroll has become problematic.
For many patients, the hypermobile joints become problematic.
"The Joyce thing has become problematic.
Plans for the election have already become problematic.
In each case, the trees have naturalised and become problematic invasives.
Yet Altman worries that the network's very potency has become problematic.
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