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The yellowing can become problematic especially in fine art drawing rather than newsprint where text can often still be read.
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With less than 50 presumably unrelated individuals [there are 53 individuals reported as unrelated in the HapMap ASW dataset, even if we ignore the relationships reported here and in Pemberton et al. (2010)], the estimation of allele and haplotype frequencies becomes problematic, especially in an admixed population like ASW.
Communication with staff can become problematic, especially when children have additional needs necessitating clear lines of communication.
This becomes problematic especially for tumor samples where the majority of the genome is often not expected to be diploid.
This can become problematic in patients with stenotic coronary arteries especially when tachycardia is present, which can decrease diastole-dependent left ventricle perfusion.
Eating meat, something I have always enjoyed doing, has become problematic in recent years.
However, it too has become problematic when used in excess.
If the trend continues, it could become problematic for the Republican leadership, especially if it is interpreted as a lack of confidence in the party's opposition stance.
"That's problematic, especially in this economy," he said.
Migration is problematic, especially in estimating populations for small areas.
Differentiating residual or recurrent cancer from scar tissue is problematic, especially in patients with ongoing symptoms.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com