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Thus X-ray studies of extremely disordered proteins tend either to focus on the ordered domains of the proteins that can be readily crystallized, or are studies of protein complexes where some disordered domains become ordered on binding.
A number of these interactions occur within the structurally conserved domains of MTA1, but others are directed through intrinsically disordered regions that become ordered on binding and are key to forming a stable NuRD complex.
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It seems likely that this loop becomes ordered on binding by another protein, for example one of the other members of CBF3.
BBL becomes ordered on biotin binding and then adenylate binding site is formed in EcBirA.
Markus et al. reported that a loop of the L11 RNA binding domain becomes ordered on binding although the loop is absolutely unstructured without the partner RNA [ 3].
L3/4 is commonly disordered in apo-SA ('open' conformation) [ 28], but becomes ordered on biotin binding, closing over the binding pocket and forming a 'lid' over the bound biotin ('closed' conformation).
Genomes have likely evolved to become ordered by replication timing on many occasions, some ancient.
The aim of the update process is to make neurons more like the input vector; the end result is that the neurons on the map become ordered and neighboring neurons are similar.
Chaos would become order.
Their suggestions become orders.
My suggestions become orders.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com