Sentence examples for become nonresponsive from inspiring English sources

Previous work by us and others has found that macrophages and dendritic cells, important reservoirs of in vivo infection, become nonresponsive to Toll-like receptor (TLR) and IFN-γ receptor activation [3], [4], [5], [6], [7], [8], [9].

63 Blocking the PD-1 pathway is thought to modulate the activity of T-cells that have become nonresponsive after encountering PD-1 ligands in the tumor microenvironment.

In the clinic, studies have shown the need to gradually increase the dose of MTX in order to achieve an optimal therapeutic benefit, and some people will eventually become nonresponsive to MTX.

However, there are some indications that, in obesity, the POMC neurons in the ARH become nonresponsive to leptin (this has been termed leptin resistance), and this may limit how much the actions of leptin can be transduced by the POMC neurons in the ARH (Enriori et al., 2007; Knight et al., 2010; Münzberg et al., 2004).

When they bind their ligands (CD80 and CD86 [B7 molecules] for CTLA-4; programmed death ligand-1 [PD-L]1 and PD-L2 for PD-1), the T-cell effector functions are dampened or stopped, and the T-cell can become nonresponsive.

He was left to care for her on Tuesday, and during their time together he hit her with a closed fist, caused her to fall and strike her head in the bathtub and shook her roughly when she became nonresponsive, according to a police account of his statements.

After retinal lesioning, many neuronal clusters inside the LPZ became nonresponsive to our mapping methods.

One potential strategy could be to convert an endocrine nonresponsive tumour to become responsive to oestrogen-induced apoptosis by blocking the survival pathways with the expanding list of tyrosine kinase inhibitors and antibodies that block cell surface signalling.

Instead, population 4 could have become homogeneous for daylength nonresponsiveness via a founder effect operating on a population that contained a mixture of responsive and nonresponsive types.

It is thus the magnitude of candidate gene expression within the nonresponsive G12 explants that suggests the physiological response of a primordial shoot explant, particularly during the early stages of SE induction, could determine its ability to become responsive to SE induction.

It's the first time that Mr. Phoenix has been booked on that show since his notorious appearance on Feb. 11, 2009, when he gave Mr. Letterman a largely nonresponsive interview that became a viral sensation and left viewers wondering whether Mr. Phoenix was playing an elaborate prank on the host and his audience.