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Each of these topological folds encompasses a major VH gene family that become juxtaposed in pro-B cells via megabase-scale chromatin looping.
In the three-dimensional structure of a protein, amino acids creating the epitope can be discontinuous and become juxtaposed at the surface of the antigen through protein folding.
When a protein folds into its native conformation, amino acid residues that are distant in the sequence (one dimension) become juxtaposed in three dimensions such that the sequence cannot be accurately "read" without denaturing the protein.
The subsequent identification of IGH (previously IgH) and MYC (previously c-myc) as partner genes that become juxtaposed and dysregulated as a result of this translocation spelled a new paradigm in the mechanism of oncogenesis (Klein, 1983).
At 5 somites, when the two neural folds become juxtaposed, we found that Snail2- and E-cadherin-expressing cells (Fig. 3Aa) within the neural fold (Fig. 3Ad) exhibit reduced apical expression of ZO1 compared with cells found more ventrally or laterally (yellow dotted lines, Fig. 3Ae).
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Alternatively, organelles may rapidly connect one to another by means of membrane contact sites (MCSs), where their membranes become closely juxtaposed (10 30 nm).
STAT6 monomers bind via their src homology 2 domains to the phospho-tyrosine residues within the intracellular portion of IL-4Rα and become phosphorylated by the juxtaposed Janus Kinases.
Black deco gradually settled into a style ripe for marketing, and black juxtaposed with white became the vogue.
If there is an initial urge to stimulate erotically, it becomes defused or dissipated by the semi-abstraction of the juxtaposed colour.
It became a marker as in Japanese prints and was applied in juxtaposed areas.
Within two years, Signac embarked on some of his most daring experiments in what became known as Divisionism, because the idea, inspired by scientific speculation, was to break up color into juxtaposed spots.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com