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There is also some lineage continuity at the level of the PM precursors of the Node/primitive streak border which were shown to become internalized to become part of the chordo-neural hinge in the tail-bud.
(To be clear, this is not an all-or-none phenomenon; rather, there are degrees of relative autonomy, as extrinsic motivation may become internalized to a greater or lesser extent [ 3]).
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By fitting the data with a sigmoid function, the mean+/−standard deviation of the t1/2 for phagosomes containing FITC/InlA-beads to become internalized and acidified was calculated to be 23.2+/−0.8 and 32.1+/−0.2 min for MDCK and Caco-2, respectively These combined results demonstrate that the FITC/InlA-beads curve lags behind the Alexa488/InlA-beads curve (Figure 3A and 3B).
This can be attributed to the fact that the Alexa488/InlA curve is only a measure of the time it takes for bead internalization whereas the FITC/InlA-beads curve is a measure of the time it takes for a bead to become internalized and then for the phagosome to become acidified.
Similarly, confocal microscopy revealed refractoriness of α2AAR-YFP/CFP to become internalized following stimulation, whereas upon activation with CCL2 CCR2 was readily detected on endosomal structures (Figure 4B).
Importantly, unfolding alone did not enable HLA to bind to cell membranes, become internalized or kill carcinoma cells.
Such layers of taunting which become internalized and self-scorn can create longstanding scars, especially to a fragile psyche, as Jonathan Martin's was purported to be.
These mixed organic and inorganic nanoparticle composites bind to the cell surface and become internalized by mESCs, providing an efficient nonviral method of gene delivery.
Self-determination theory proposes that people are more likely to persist with behaviors that are internally-motivated, and that externally-motivated behavior can evolve and become internalized given the appropriate socio-environmental conditions.
Activation of the canonical HH signaling pathway comprises the binding of HH ligands to the membrane receptor Patched (PTCH1), which becomes internalized leading to the activation of the signaling molecule Smoothened (SMO) via release from PTC-mediated suppression.
The appearance of this lower pH peak indicates that a portion of the beads have become internalized and exist in acidified phagosomes.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com