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In the past decade, however, oncology has become increasingly understood on a cellular and molecular level, with many cancer subtypes being described as a function of biomarkers or tumor genetic mutations.

As cancer has become increasingly understood on the molecular level, newer "targeted" drugs that inhibit specific cancer cell growth and survival mechanisms have increased the need for new clinical trial designs, wherein pertinent questions on the relationship between patient biomarkers and response to treatment can be answered.

While it has become increasingly understood that MAPK signaling is an integral part of cellular non-immune defenses to bacterial PFT, the mechanisms involved in temporal regulation of these pathways are less clear.

While there was limited information on the potential function of PTPN11 polymorphisms, biological characteristics of SHP-2 have become increasingly understood.

It has become increasingly understood that breast cancers segregate by gene expression into different intrinsic subtypes, with the assumption that cancers falling within the same subtype share a similar prognosis and suggested therapy method [ 51].

Similar(55)

During the early time of arthroscopy the importance of saving the meniscus became increasingly understood.

In parallel, underlying mechanisms of antibody-mediated tissue injury have become increasingly better understood [ 48].

The importance of sustainability and recycling has become increasingly recognised and understood in academia and industry over the last several decades.

Developments in studying single-cell genomic architecture have become increasingly deployed to understand the relationship between topology and phenotype.

Therefore, predicting a series of cis-elements that function cooperatively has become increasingly important to understand transcriptional regulation in higher eukaryotes.

Researching such linkages will become increasingly important to understand the conditions under which policies to encourage greater rural out-migration should be preferred to a targeted strategy to overcome poverty in remote and fragile areas.

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