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Running trials at academic institutions has become increasingly difficult, particularly because many peer-reviewed funding agencies often systematically under-fund clinical trials in the peer review grant process.
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Third, maintaining high response rates in surveys and longitudinal studies has become increasingly difficult over time, particularly using telephone methods, as the percentage of the population who uses mobile phones increases.
Raising the massive up-front capital to construct new full-scale reactors has become increasingly difficult in the United States, particularly after ballooning budgets for two plants in Georgia and South Carolina ended up tipping Westinghouse Electric into bankruptcy, nearly taking its parent company with it (see "Meltdown of Toshiba's Nuclear Business Dooms New Construction in the U.S".).
But with moose becoming increasingly rare, capturing food become increasingly difficult.
But in the current economy, real estate executives and bankers say, it has become increasingly difficult for developers to obtain loans for real estate projects, particularly one as troubled as Mr. Kennelly's.
Because Impressionist and modern art has become increasingly difficult to find these days, collections from estates, which have generally been off the market for decades, are particularly coveted.
Juggling both has become increasingly difficult.
Orchestra management has become increasingly difficult.
Optimal controls and laboratory experiments become increasingly difficult.
And it had become increasingly difficult to find work.
It has become increasingly difficult to do that.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com