Type BI/NAP1/027 strains of C. difficile have recently become highly represented among clinical isolates and are associated with increased disease severity.
In recent years, certain C. difficile types have become highly represented among clinical isolates and are associated with outbreaks of increased disease severity, higher relapse rates and an expanded repertoire of antibiotic resistance.
Mutations that lead to a large fitness advantage, such as UBP7, may become highly represented in the initial mutant pool and lead to over-representation of non-productive mutations found in the same strain through genetic linkage.
Another significant sweep was the malT change from day 14, which also, as previously observed (Notley-McRobb and Ferenci 1999b), became highly represented for the rest of the experiment.
Although the absence of clonal analysis and studies of proliferation cannot exclude that a tinny proportion of proliferating endothelial cells became highly represented in the cultures, these studies suggested for the first time the existence of a novel subset of cells with vasculogenic potential.
For example, code words at the top of the heatmap become more highly represented in the repertoire of immunized mice, while code words at the bottom are less represented.
During this process, chordamesodermal cells of the Xenopus gastrula become highly polarized, become spindle-shaped representing polarized intracellular events, and intercalate between each other mediolaterally, via active protrusions [1], [2], [3].
"Every species leap [by H5N1] represents a new virus mutation, increasing the chance that one will become highly infectious to humans," says Dr Peter Horby, an epidemiologist at the World Health Organisation (WHO), in Hanoi.
However, due to the low dimensionality of the 'effective' model parameter space spanned by the parameters γ ̲, the direct feature extraction may become highly unstable, except where the parameter set { a k } is sparse or the parameters γ ̲ k, η ̲ k representing the sub-models show highly restricted variability.
"Chelsea has become highly upscale," he said.
The province has become highly industrialized.
