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A few become handicapped to the point of requiring a wheelchair.
But the only real difference between "opera" and "Hamilton" is that "opera" has become handicapped by what it is thought to signify — by the idea that it is thought to represent some sort of pinnacle of high art.
The danger of this is like a healthy person gradually relying on a wheelchair, causing him or herself to become handicapped in the end.
The process of MSC aging is important from the perspective of tissue regeneration and repair because there is evidence that these beneficial functions may become handicapped with age.
Patients who experience frequent relapses in the early stage of disease and those who accumulate a large number of focal lesions visible on 2-T (T2) magnetic resonance imaging (MRI) within the first 5 years become handicapped more quickly than those patients who do not [ 6– 8].
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Some authors have suggested that malocclusion might become handicapping not because of the functional disability, but because it can adversely affect social relationships and self-perceptions [ 36].
"I used to get very upset when I was in my 50's and couldn't get a place to park," said Diana Spirt, who is 78 and became handicapped at age 52.
Once Peter becomes handicapped, a montage of his difficulties as a paraplegic is shown, with Elton John's "I Guess That's Why They Call It the Blues" playing in the background.
"One of my own sisters became handicapped for life soon after her wedding as a result of a difficult pregnancy at a young age".
Analyses of anomalous nucleotide composition is quite effective in the detection of recent LGT events but becomes handicapped as the time scale of the event in question increases typically because the gene in question has more time to adjust to the host genome [ 50].
Nevertheless, as she demonstrates, these anatomical changes don't need to become handicaps.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com