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As the driving mechanisms of leukemia pathogenesis become further defined, and the inhibition of said mechanisms at a molecular level are correlated to clinical response, future studies should enroll patients on the basis of these molecular features, perhaps in isolation of clinical features, as variables such as age and secondary disease are intermediate markers for underlying pathobiology.
Undoubtedly, the publication of this article will lead to further reporting of patients with mutations in the ASXL gene family, and the clinical features of this ASXL3 mutation syndrome will become further defined.
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The circulation and convection became further defined, and the National Hurricane Center estimates the system developed into Tropical Depression One late on July 14 about 45 miles (75 km) west-southwest of Hatteras, North Carolina.
Evidence for the benefit of neoadjuvant chemotherapy with the objective to improve resectability rates was already established in 1996, at which time it was shown that initially unresectable metastases could become resectable (further defined as secondary surgery) after downsizing by chemotherapy [ 3].
In future, results from these prospective clinical trials will become available to further define the role of chemotherapy followed by CRT for LAPC.
With the diversification of patient population in the United States and worldwide, it has become imperative to further define prognostic factors and treatment modalities on the basis of racial dissimilarity.
The target population will be further defined when additional data become available.
Tibial torsion is a well known anatomical feature of the tibia; it was first described in the early 1900s and was further defined as soon as CT investigations became available (Le Damany 1909, Jakob et al. 1980, Takai et al. 1985).
"Ten years ago, courage was further defined".
The terms mood and spirit can be further defined.
But how should the area be further defined?
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com