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In all cases, however, the cells become fully senescent around generation number 100.
Furthermore, T cells in aged individuals never become fully senescent because IL-2 cytokine can restore their function.
They indicated that although ATM activation and γ-H2AX foci formation were induced by telomere dysfunction as a stress response in late-passage presenescent cells but not in early-passage cells, they disappeared once cells become fully senescent.
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Furthermore, the numbers of foci for these two markers were significantly reduced after the cells became fully senescent.
However, these DSB markers were significantly reduced once cells became fully senescent, suggesting less necessity for DNA damage/repair function in that stage.
I have become fully engaged.
Shares become fully vested after five years.
Not until 2006 will the reductions become fully effective.
After a decade or two the dividends become fully taxable.
After losing immunity, individuals become fully susceptible again.
Thus, early tumors may become fully enclosed or "sealed off".
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