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During classical cellular differentiation cells lose phenotypic plasticity until they become fully differentiated.
Indeed it is possible that its function might have only become fully differentiated to serve as a control of muscle mass in mammals.
From skin cell to brain cell: Skin cells that have been "reprogrammed" to act as stem cells (top) can be grown in culture until they become fully differentiated neurons (middle).
The configurations of the fingerprint enlarge as the hands and feet grow, but the characteristics of the print remain unchanged once the dermal ridges become fully differentiated at about the 17th week of fetal development (Hale 1952; Babler 1978; Borecki et al. 1985).
During morphogenesis, totipotent stem cells become the various pluripotent cell lines of the embryo, which in turn become fully differentiated cells.
1 Breast epithelial cells do not become fully differentiated until after the first full term pregnancy.
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Thereafter, the cells were maintained in 10% FBS-DMEM with media changes every other day until they became fully differentiated.
Data from Hiroshima and Nagasaki, as well as from the treatment of young women with Hodgkin disease, show that the breast is not protected from potentially harmful environmental agents until it becomes fully differentiated in preparation for producing milk.
Considering the main biological obstacles to cartilage repair as outlined in this review, an ideal construct would contain hyaline differentiated tissue, and become fully integrated with the adjacent cartilage and bone, without the induction of an inflammatory response, senescence, apoptosis or necrosis.
In our study, expression of CD62L, CD27, CD57, Siglec-9 and FCRL6, suggests that CD56dimNKG2A−KIR− NK cells are not fully differentiated, but can be re-educated under specific stimulation to become fully functional, in line with our model (Fig. 7).
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