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The probability for an Apc mutation, for example, to become fixed, that is, to populate the whole crypt is 42% (PR=0.62, N=5 stem cells), which means in the majority of cases the mutated cell will be replaced by one of its wild-type stem cell neighbours and will be consequently lost.
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It is possible that more strongly deleterious mutations have become fixed at this stage, a hypothesis that could be tested in the future by linkage mapping of heterosis in crosses between SC populations.
Narrative films can have such an overwhelming storytelling force that most filmgoers have become fixed on that level: They ask, "What's it about?" And the answer satisfies their curiosity about the movie.
Is there a danger that if they describe it as one thing – the "diversity western", say, or the "anti-Trump allegory" – then it will become fixed as that forever?
These cropped black-and-whites, these images that have become fixed in public memory, that have gone to make that memory, are dominated by a single, mythical name: Swinging London.
The results suggest that in the early stages of a pandemic, mutations that occur during replication do not become fixed so that a uniform consensus strain circulates for some time.
The results suggest that in the early stages of an influenza A pandemic, mutations that occur during replication do not become fixed so that a uniform "consensus" strain circulates for some time.
Decay might arise because markers close to QTL become fixed such that the distance between the nearest polymorphic marker to a polymorphic QTL increases, and recombination more rapidly reduces accuracy.
Scientists had previously believed that the old carbon was inaccessible because it had become fixed in the soil; that belief has become a magnet for new studies and controversy.
The mean number of alleles that become fixed can then be calculated as | G | fix = | G | ∫ 0 α max p Π seg d α, (27 where the integral equals the normalization constant in Equation 19 (i.e., the proportion of fixed alleles).
Such "foreign" alleles that become fixed in a new population or species will often be viewed post hoc not as the result of hybridization, but simply as ancestral shared states that never diverged.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com