The NL peak can easily suppress sequence diagnostic ion peaks causing identification of the peptide to become extremely difficult and sometimes impossible.
However, as the lateral dimension goes smaller and smaller, these 'top-down' approaches become extremely difficult and expensive, hence, other methodologies of creating nanostructures are of great interesting if they can offer advantages in reduced production cost, smaller feature sizes, and more complex nanopatterns.
So comparing the public and the private sector becomes extremely difficult and taxpayers cannot tell whether they are getting a good deal.Creditors, as well as taxpayers, are waking up to the scale of the problem.
"When that breaks down, it becomes extremely difficult and potentially fraught," Shawn Brimley, a former White House official now with the Center for a New American Security, said of the need to protect the military's nonpolitical role.
But she told Sky News' Murnaghan: "If you try and take everybody's phone numbers, everyone they are calling on the phone and also emails, it becomes extremely difficult and I think that's the point where civil liberties rubs up against actual investigation into potential people and we need to be very careful".
When dealing with massive amounts of data (on the order of terabytes or petabytes, for example), intrusion detection becomes extremely difficult, and single computers cannot handle the sheer size of data.
As the war intensified and officer casualties mounted, the ability to replace casualties with officers of British origin became extremely difficult and in many cases the officer allotment to battalions was reduced accordingly.
Indeed, Sony's patent notes that through the complexity of its copy-protection scheme "manufacture of counterfeit software becomes extremely difficult". And it's not unusual for technology companies such as Sony to register patents either in anticipation of one day collecting royalties from someone seeking to license the technology or to prevent someone else from deploying it.
Since 9/11 cockpits doors have been fortified to become extremely difficult to bypass, and such a sudden incident could perhaps have incapacitated both pilots while keeping out the rest of the crew.
By Laurent Duvillier Delivering life-saving vaccines and medicines has become extremely difficult since the outbreak of conflict in Central African Republic, but UNICEF and its partners continue their efforts to reach as many children as possible.
