T cell activation, as determined by the presence of surface expression of HLA class II (known from in vitro to become detectable at 2-3 dafterfter stimulation), was found to be strongly enhanced in the EBV patients, and notably not only in the CD8+ T cells but also markedly, although to a lesser degree, in the CD4+ T helper cells.
However, they might become detectable at later time points, when the virus was allowed to spread throughout the culture.
In normal conditions, serum PCT levels are negligible, but they become detectable at the onset of infection.
Although synaptic genes are the most consistently affected functional group, in TASTPM mice, these alterations in gene expression frequently become detectable subsequent to the changes in synaptic transmission and thus effects on synaptic gene expression may be the result, rather than the cause, of the synaptic changes.
What caused these miRNA* sequences to become detectable after exposure to RDX is unclear.
Although T lymphocyte HLA-DR, being an MHC class II molecule, does not directly participate in T cell activation, and seems not to be expressed in most T cells, its presence on the T cell surface is known to become detectable in response to virus infection.
One of the most important current diagnostic tests, the microscopic agglutination test (MAT), which is often used as the gold standard, is based on serology and can only confirm the disease at a later acute phase because anti-Leptospira antibodies generally become detectable only 5 to 7 days after onset of illness.
Real-time PCR provides quantitative results, since the cycle number in which amplicons become detectable is proportional to the logarithm of initial number of templates.
Antibodies to Leptospira may take several weeks to become detectable by MAT [ 21].
It is well established that serological response to HPV-infections needs several months to become detectable [ 25, 29].
