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IM is an ATP-competitive inhibitor and owes its success to the exploitation of oncogene addiction, a phenomenon in which a tumour cell has become critically dependent on a single oncogenic pathway for its proliferation and/or survival [ 4- 6].
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Thus, the diagnosis becomes critically dependent on accuracy, that is, the consistency of a practical assessment of a symptom with its true value.
This illustrates that as the tumour expands it becomes critically dependent on new vessel formation and the drug modulates the balance of pro- and inhibitory angiogenic factors, mirroring the earlier experience indicating that antiangiogenic agents are more effective when given over a longer term (Ciardiello et al, 2003).
This example is critically dependent on the first number the 163 species found only on the one species of tree.
"We're critically dependent on mass," said Dr. Brownlee.
"Our economic system is critically dependent on the free flow of credit".
Both are critically dependent on revving up the institute's research role.
We at Google are critically dependent on this infrastructure building out".
"Our economic system is critically dependent on the free flow of credit, and the consequences for the broader economy of financial instability are thus powerful and quickly felt".
"We have enormous segments of agriculture that are critically dependent on hired farm labor," said Keith Collins, the chief economist at the Agriculture Department.
Our capacity to draw happiness from aesthetic or material goods seems critically dependent on first satisfying a more important range of emotional or psychological needs.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com