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Coiled-coil proteins may be exposed to the immune system as surface structures in aberrant disease states associated with unregulated cell death and could become autoimmune targets [ 30].
In several spontaneous models, the genetic abnormalities that cause the loss of tolerance must be expressed in those B cells that become autoimmune [ 3].
In addition, recent works suggest that the paranodal and juxtaparanodal axo-glial components could become autoimmune targets (see above) (Mathey et al., 2007; Derfuss et al., 2009).
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How this family of coiled-coil proteins becomes autoimmune targets remains to be determined.
But looked at another way, by the women and progressives being called a "social justice warrior," the oncology becomes an autoimmune disorder: the immune system is attacking a healthy portion of its own body.
Our model shows that the pathologic dynamic regime in autoimmune conditions become stationary and makes the autoimmune process chronic but relapsing instead of progressive.
See related editorial by Lundberg and Venables, Post-translational modifications can create neo-antigens that become targets of autoimmune responses [ 1, 2].
Anti-N-methyl-D-aspartate receptor (NMDAR) encephalitis is an autoimmune neurological disorder caused by production of antibodies to NMDAR and has become the most common autoimmune encephalitis described, since its first description in 2007 [1].
Animal models have been useful in identifying self-antigens that become the focus of autoimmune attack and genetic loci that control susceptibility to disease.
You already knew this: The older we get, the more susceptible we tend to become to infections, cancer, autoimmune disorders — in short, to all the things you don't get when your immune system is acting like a just-off-the-lot Ferrari instead of a rattling, rusty jalopy.
Indeed, obesity-induced insulin resistance is believed to up-regulate the β-cells, which become susceptible to an autoimmune attack [39].
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com