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If genome location produces systematic biases in expression levels, selection could act on gene position and cause more conserved and expressed genes to become associated with replication origins.
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Whereas ORC remains bound to ARS sequences throughout S phase, Cdc45p and other initiation factors such as the minichromosome maintenance (MCM) complex become associated with the advancing replication fork [ 5, 6].
A growing number of disorders have become associated with mtDNA instability, primarily a result of impaired mtDNA replication.
The parade has become associated with violence.
Sadly, corrective responses to misconduct have become associated with punishment.
Subcultures often become associated with place".
Thus, our data indicate that Hat1p becomes associated with origins of replication around the time of origin firing and later with non-origin sequences, such as Cdc45p, suggesting that Hat1p also associates with advancing replication forks.
Differences in allele frequency could also result in a reversal of allelic effects where a putative protective allele becomes associated with increased risk in a replication study.
Through him she became associated with Communism.
His name became associated with musical perfection.
Suicide bombing became associated with Islam.
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