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However, identifying these effects has become an extremely difficult problem, with the number of potential tests dwarfing the number of samples available for analysis.
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"Northern Ireland's an extremely difficult place to become very successful," he said.
At a certain point, though, the changes will become so great that adaptation will become extremely difficult; a five-foot rise in sea levels, for example, would put parts of the state of Florida underwater.
Earning a living has become extremely difficult, she said: "I can work for an hour, and then I need to rest.
In such a context predictions become extremely difficult.
Even a simple act such as standing up from a chair and walking a few steps can become extremely difficult.
American, European and United Nations officials say the establishment of a new government has become extremely difficult because of the mistreatment of some Iraqi prisoners and the continuing American military actions in Falluja, Najaf, Karbala and elsewhere.
So it would become extremely difficult to win an antidumping case if China were labeled a market economy.
If wannabe social networks can't piggyback on Facebook, or the non-API-offering Google+, and not now Twitter either, it may suddenly become extremely difficult to get the scale you need to break through.
It would become extremely difficult to pursue under a system of three year undergraduate degrees.
Should they converge into a kind of "perfect storm", however, a return to sunny days will become extremely difficult to foresee any time soon.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com