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Platelets become activated when the continuity of the endothelial layer is disrupted and the underlying subendothelial matrix is exposed, or if inflammation perturbs the endothelium.
Natural killer (NK) cells become activated when the receptor NKG2D is engaged by ligands that are frequently upregulated in primary tumors and on cancer cell lines.
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Interestingly, the UPR can be viewed as a general response of A. niger, which becomes activated when the secretion machinery becomes challenged by metabolic changes or ER stress conditions.
Notably, a more anterior and dorsal portion of the DLFC became activated when the adjectives offered as the decision criteria were presented and the subjects had to make a decision (forced choice paradigm).
We found the right DLFC to be involved in both decision stages at clearly different positions: a posterior portion became activated when the actual decision was made as indicated by the subject's button press (decision).
These sensors become activated when either the K9 or K27 become methylated and bind with the Suv39H1 or Pc2 domains that bring two halves of split-RLuc together, reconstitute its enzymatic activity, and activate bioluminescence that can be imaged in cells in vitro, and in vivo in living animals.
By comparing our model predictions with experimentally measured dose-response curves from the literature, we propose that some proteins bind CaM without Ca2+ ions and only become activated when Ca2+ ions interact with the CaM-target complex, whereas others are activated by CaM molecules with already bound Ca2+ ions.
Moreover, our results also demonstrate that the PLCζ expressed within CHO cells is either already active, or can subsequently become activated when it is assayed in vitro or introduced into eggs, thus implying that PLCζ may be held in an inactive state in CHO cells.
NK cells become activated when signals from inhibitory receptors decrease, such as when the expression of KIR-binding MHC molecules on virus-infected cells decreases, or when signals from activating receptors increase, such as when antibody-coated viral antigens and/or stress-induced ligands on infected cells are recognized.
As the joint continues to deteriorate, these "sensitized" nerve fibers then become activated when noxious or nonnoxious mechanical stimuli are applied to the joint (see [ 1, 18- 20] for review).
Mechanosensitive proteins embedded in the plasma membrane which become activated when cells are deformed [for example those reviewed in Monshausen and Haswell (2013), e.g. stretch-activated channels] can indirectly trigger responses to turgor changes.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com