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Although K15-positive stem cells in the mutant bulge are comparable in number to the control, their ability to proliferate and become activated to form a hair germ is reduced.
In vivo, lymphocytes often receive multiple stimuli and become activated to carry out their biologic functions.
In response to bacterial antigens, NKT cells arrest and become activated to secrete cytokines.
Fibroblasts are derived from MSCs and like their precursor cells they can adapt immunoregulatory properties and become activated to secrete growth factors in case of tissue injury.
In response to lipid antigen, these NKT cells arrest in close proximity to antigen-containing cells in the MZ and become activated to secrete cytokines.
Platelets then become activated to trigger subsequent aggregation of other locally activated platelets via fibrinogen-mediated interactions with activated platelet integrin GPIIb-IIIa.
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After inflammatory response is triggered, adaptive immunity becomes activated to effectively protect the host and to establish a memory immune response.
It is possible that these areas became activated to compensate for nigral dopamine depletion in patients with PD and that ACUP may calm these areas down to normal activity levels, as observed in healthy participants.
Dissections to release sperm were accomplished by cutting in front of the tail with a hypodermic needle [ 74], and released spermatids were observed as they became activated to form spermatozoa within 5 minutes on a Zeiss Axioskop with DIC optics.
The cytokines have other consequences, one of which is that IL-2 allows cytotoxic or regulatory T cells that recognize the same antigen to become activated and to multiply.
Moreover, P-gp does not affect the ability of T cells to become activated, pointing to a distinct mechanism during EAE pathology.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com