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The phrase "become a major problem" is correct and usable in written English.
It can be used to describe a situation or issue that has increased or worsened significantly over time, causing significant difficulty or concern. Example: In recent years, pollution has become a major problem in our city, impacting the health and well-being of residents and damaging the environment.
Exact(60)
This could quickly become a major problem.
Drug-resistant bacteria have become a major problem.
Tunneling currents become a major problem with shrinking device geometries.
Getting out the wounded has become a major problem for the Ukrainians.
"ENVIRONMENTAL pollution has become a major problem, which is nature's red-light warning".
The low turnover rate is probably one reason long-term unemployment has become a major problem.
Ebola is unlikely to become a major problem in the developed world.
Cuts and closures have become a major problem across the country.
Getting enough people to enlist could become a major problem for the next president.
For example, obesity has become a major problem in the developed world.
How to accurately measure performance of R&D staff has become a major problem.
More suggestions(15)
become a substantial problem
become a sizeable problem
become a large problem
become a pivotal problem
become a severe problem
is a major problem
becomes a major problem
demonstrated a major problem
becoming a major problem
were a major problem
become a main problem
discovered a major problem
became a major problem
become a leading problem
assumed a major problem
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com